A second example is someone in early sobriety who cannot feel pleasure even on objectively positive days, because their dopamine system is still recovering from chronic substance use
125 GCGR knockout mice produced in one study had islet alpha-cell hyperplasia and these mice were additionally shown to have large increases of glucagon and GLP-1 levels in circulation, but interestingly they had lower plasma glucose levels throughout the day, similar insulin levels and improved glucose tolerance compared to GCGR+ control animals
When to seek medical advice : Patients should contact their GP, diabetes specialist nurse, or NHS 111 urgently if they experience: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Persistent vomiting (unable to keep down fluids for more than 24 hours) Signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Fever, jaundice, or right upper abdominal pain (possible gallbladder disease) If nausea significantly impacts their ability to maintain adequate nutrition These symptoms may warrant dose reduction, temporary treatment interruption, or switching to an alternative GLP-1 preparation with a potentially better tolerability profile
Accessed 10/25/2022, Weber PC
Thankfully, there is a cheat to help liven things up between the sheets: Glutathione
