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In contrast, sublingual formulations, such as cannabinoid tinctures, and oromucosal preparations, may offer more predictable pharmacokinetic profiles by partially bypassing first-pass metabolism and enabling more direct systemic absorption (Kaufmann et al., 2022)
Major JM, Laughlin GA, Kritz-Silverstein D, Wingard DL, Barrett-Connor E: Insulin-like growth factor-I and cancer mortality in older men