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(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents

In conclusion, the activation and promising application of GLP-1R offer broad possibilities for the future treatment of diabetes and related diseases

Eight major RCTs of GLP-1RAs have investigated the cardiovascular outcomes, including the ELIXA trial of lixisenatide (250), the EXSCEL trial of exenatide ER (251), the LEARDER trial of liraglutide (252), the SUSTAIN-6 trial of subcutaneous semaglutide (253), the HARMONY trial of albiglutide (228), the REWIND trial of dulaglutide (254), the PIONEER trial of oral semaglutide (255), and the SELECT trial of subcutaneous semaglutide (199)

In 1934 he fled to New York in the USA where he worked as a clinician in private practice (de Levia, Brugus, de Leiva-Prez)

Influence of Production Process and Scale on Quality of Polypeptide Drugs: a Case Study on GLP-1 Analogs