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Glutathione is synthesized in two sequential enzymatic reactions: glutamate cysteine ligase (GCL) catalyzes the first, rate-limiting step, and glutathione synthetase couples -glutamylcysteine to glycine in the last step [13]

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Although predominantly expressed in the adipose tissue 4 , PPAR messenger RNA and immunoreactivity has also been detected in hypothalamic nuclei governing energy balance 5 , and third ventricle adenoviral-mediated overexpression of PPAR decreases food intake in lean and diet-induced obese (DIO) mice 6

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