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It also reflects the distribution of sulfur and one-carbon metabolism between methionine recycling, methylation and antioxidant production

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The passage of metabolites such as ATP, adenosine diphosphate (ADP), pyruvate, calcium ions (Ca 2+ ), and phosphate (PO 4 ) is regulated by controlling the transport proteins

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In this work, we aim to provide a comprehensive review of IGF-1 signaling in health and disease, including the most recent proposals regarding its context-dependent actions and important areas that require further study, as our current understanding of IGF-1R pathways remains limited