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In Cohort 1, 25 WT and 25 RAMP1/3 KO male mice aged 1220 weeks old were injected intraperitoneally after a 12-hour fast with vehicle, sCT at doses of 3 or 150 nmol/kg, or Cagrilintide at a dose of3 nmol/kg

A similar finding has been reported in earlier studies in which a motif upstream RI was described as an immunologically cryptic epitope in mice immunization studies (31)

The compound reduces plasma creatine kinase levels (a marker of muscle damage) and decreases malondialdehyde concentration (indicating reduced lipid peroxidation) in exercised muscle tissue

Such risks underscore the importance of professional oversight in drug preparation