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It is produced in cells and is made up of three amino acids: glutamine, glycine and cysteine

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10.2337/db08-0792 35 HolmanR

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112 DAN encompasses multiple subtypes, including cardiovascular autonomic neuropathy (CAN), gastrointestinal autonomic neuropathy, genitourinary autonomic neuropathy, sudomotor dysfunction, hypoglycemia unawareness, and pupillary dysfunction, each affecting different organ systems and presenting a spectrum of clinical manifestations