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This is one proposed explanation for folic acid anxiety , worsening depression, obsessive thinking, insomnia or emotional flattening in susceptible undermethylators

Those observations are included here only to summarize research context

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Twenty-seven programs are racing into a category where the mechanism is known, the readouts are imminent, and the market is larger than any drug class that has ever come before

(38) measured and then compared occipital cortex (COC) GSH levels in unmedicated adults with MDD to healthy participants and found 21% lower GSH levels in MDD patients