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"If you have or suspect you're at risk for Type-2 diabetes or a cardiovascular condition, ask your doctor if a GLP-1 drug may be part of an appropriate treatment regimen," Abernathy says
Evidence for separate roles Several lines of evidence support the notion of distinct roles for peripheral and central GLP-1 in appetite regulation: Differential breakdown: Peripheral GLP-1 has a very short half-life in the blood (around two minutes) due to enzymatic degradation
T cells that have been recruited to atherosclerotic plaques likely experience increased cell death, which may further stress efferocytes and contribute to an inflammatory microenvironment 87,88
Science 324 , 261265 (2009)
This creates an interesting mechanistic distinction
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