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All procedures and experiments were approved by the Ethics Committee of Army Medical University (Chongqing, China) and performed, according to the guidelines of the National Institutes of Health for the Care and Use of Laboratory Animals [53, 54]

Joint discomfort and numbness become real concerns at these doses

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No imputation of missing follow-up data was performed

If tracking food and exercising intensely feels like punishment you are enduring rather than a routine you can sustain, continuous treatment at maintenance doses may prove less stressful overall