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Studies have implicated OS in IR and DM through insulin signaling, insulin-induced GLUT 4 translocation and glucose uptake via insulin receptor substrate (IRS) phosphorylation, MARK activation and ER stress

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In a further embodiment, when slightly less viscous, or slightly more fluid auris-acceptable pharmaceutical gel formulations are desired, the biocompatible gel portion of the formulation comprises at least about 50% by weight, at least about 60% by weight, at least about 70% by weight, or even at least about 80% or 90% by weight of the compound