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L-Carnitine, an amino acid derivative naturally synthesized in the liver and kidneys from lysine and methionine, acts as the essential vehicle in this transport system

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Regeneration of reduced glutathione depends on NADPH availability, and mitochondrial NADPH production is partially sustained by nicotinamide nucleotide transhydrogenase (NNT) (Ronchi et al., 2016), which activity is driven by proton motive force