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Consequently, there is debate as to whether physiologically relevant levels in men are able to reach central GLP-1 receptors in the hypothalamus and brainstem, where centrally produced GLP-1 is also thought to act as a neuropeptide (94, 95)

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Moreover, IGF-1 signaling, which is implicated in neurodegeneration, modulates astrocytic redox balance by modifying mitochondrial activity 82

Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid