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For reference, the 35 percent threshold has historically been the exclusive turf of bariatric surgery, and it was hit by basically no one on placebo (0.3 percent, which is statistical noise)

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Hyperglucagonemia increases resting metabolic rate in man during insulin deficiency

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This suggests GLP-1 drugs may act earlier in the addiction cycle, reducing cue reactivity and craving, rather than reducing reward after use