The increase of local IGF-1 binding protein prevents IGF-1 from freely exerting its biological effects [55]
Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions
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New clinical data will emerge
2015;10 doi: 10.1371/journal.pone.0132884
