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The price reflects the brand name and FDA-approved formulation

However, the accelerated approval pathway means that evidence is still interim: while part one of the ESSENCE trial demonstrated improvement in liver scarring and inflammation, it does not yet show whether semaglutide reduces the risk of serious outcomes such as cirrhosis, liver failure or liver cancer

With that promise comes a practical question: What about side effects

Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications

Not evaluated by the MHRA.