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A phase II, open-label clinical trial evaluating the effect of combined thiamin-biotin supplementation, at moderate (600 mg/day of thiamin and 150 mg/day of biotin) and high (1,200 mg/day of thiamin and 300 mg/day of biotin) dosages, in Huntingtons disease is currently underway (75)

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13 However, preclinical studies suggest that calorie and energy restrictions can hinder tumor growth and progression and increase the efficacy of chemotherapy and radiotherapy

103 KogaM.TanakaH.YomogidaK.TsuchidaJ.UchidaK.KitamuraM.et al (1998)