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This reduction in the risk of total MACE events is a clinically meaningful finding as a key treatment goal for patients with T2DM, given their elevated cardiovascular disease risk

Safety considerations (like GI tolerability, thyroid cancer precautions, and pancreatitis risk) should be discussed openly with patients

I typically recommend that patients work with their providers and health coaches to make sustainable changes before turning to medication. Simple adjustments can help you build habits supporting weight management and overall wellbeing while taking a GLP-1

As it relates to libido and mood, and to get the downstream increases on testosterone and estrogen

Macitentan (10 mg) Class: Endothelin Receptor Antagonist Used for: Pulmonary Arterial Hypertension (PAH) Metabolism: Mainly by CYP3A4 enzyme Major DrugDrug Interactions Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin) Decrease metabolism Increase Macitentan level _ Risk of liver toxicity, headache, edema Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, phenobarbital, St