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The study also showed several cardiometabolic benefits of semaglutide with significant improvement in hemoglobin A1C, body weight, and cholesterol reduction compared to placebo

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18,22 Pharmacological intervention is therefore usually required to assist in long-term weight loss in obese patients, and there several available drugs for this but they often exhibit insufficient efficacy and dubious safety

More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly