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Here, we explore the role of the intestinal barrier in driving systemic inflammation, touching upon on the consequent pathological conditions and the potential gut barrier-targeted therapeutic opportunities following these findings

AHA Journals+1 A new twist: statins, the microbiome, bile acids and lower GLP-1 In 2024, a high-quality translational study reported that statins can aggravate insulin resistance by reducing circulating active GLP-1 levels and that the effect appears to be microbiome-dependent

This study also highlights potential improvement in IBD disease course: With a background in GI and a strong interest in the scientific side of therapeutic development, Im especially excited to see how findings like this may shape the future of IBD management

This can be combined as part of your peri-operative weight loss journey

This includes the downregulation of immune checkpoint ligands and the suppression of T regs activity, thereby creating a more favorable environment for T-cell-mediated anti-tumor responses [127]