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It lowers serum 2-HG by inhibiting the -KG conversion of mutant enzymes, 1050 which has been FDA-approved since August 1, 2017, for relapsed/refactory AML with IDH2 mutations

This step can be confusing because it involves measurements, concentration, and unit conversions

Brain: A Journal of Neurology, 130(Pt 8), 21172122

Pursuant to the CSPC License Agreement, the Company received an exclusive license to develop and commercialize a novel clinical stage antibody drug conjugate targeting Nectin-4, which the Company is referring to as CRB-701, in the U.S., Canada, the European Union (including the European Free Trade Area), the United Kingdom, and Australia

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