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Evidence Quality Summary Honest appraisal of the evidence hierarchy for this stack: | Claim | Evidence Level | |---|---| | Ipamorelin raises GH via GHSR-1a | Strong: mechanistic + animal + human Phase I | | CJC-1295 raises GH and IGF-1 in humans | Moderate: Phase II RCT (N=65) | | Combination produces synergistic GH pulses | Moderate in animals

Unlike programs that require 6- or 12-month commitments, Sesame allows patients to adjust, pause, or discontinue their treatment plan based on personal goals or changing circumstances