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Upon chelation of calcium, prothrombin interacts with phospholipids in membranes and is proteolyzed to thrombin through the action of activated factor X (Xa)

"Nutrients and sperm quality: meta-analysis." Adv Nutr 2018;9:833-48

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Sikiric P., Hahm K.B., Blagaic A.B., Tvrdeic A., Pavlov K.H., Petrovic A., Kokot A., Gojkovic S., Krezic I., Drmic D., et al

The pathogenesis of SIM remains to be fully elucidated, but it is clear that SIM is multifactorial

In research contexts, it is studied as a discrete pentadecapeptide with reproducible physicochemical properties, allowing its use in biochemical, cellular, and preclinical experimental systems