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FDA-Approved Uses in the USA In the United States, semaglutide is marketed under three main brand names, each approved for specific conditions: Wegovy: Specifically FDA-approved for chronic weight management in adults with obesity or overweight individuals with at least one weight-related condition (like high blood pressure)

It is intriguing that the Phase IIb exenatide study saw a motor benefit, but limited non-motor improvements, and now this study has a significant non-motor result, but mixed motor results

Standard management of GORD is recommended, with consideration given to dose reduction or discontinuation of the GLP-1RA if symptoms persist despite initial interventions

A history of alcohol-induced pancreatitis represents an absolute indication to avoid alcohol

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