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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

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STAT3 activation in neutrophils triggers the angiogenic switch through secretion of VEGF, IL-8, TNF-, MMP9, FGF2, ANGPT-1 and HGF in mice [265,266,267]