semaglutide lean mass loss impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity - Jeromson - The Journal of Physiology Weight-loss drug found to shrink

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Tirzepatide slows gastric emptying and intestinal transit, which can worsen symptoms in patients with stenosis (narrowed bowel segments)

Some studies suggest that it may not be effectively absorbed by the gastrointestinal tract, leading to skepticism about its benefits

Confocal images were acquired with a 20x objective on a spinning disk confocal microscope