Intestinal extracts were then shown to potentiate insulin secretion in dogs and this led to the discovery of two primary gut hormones with incretin activity, gastric inhibitory peptide (GIP) and glucagon like peptide-1 (GLP-1) (10, 15, 18, 28, 75)
The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy
Transition requires starting retatrutide at the beginning of its titration schedule (1mg) and working up, regardless of your previous tirzepatide dose
Most see pills as more natural and less stressful than injections
However, some patients experience significant side effects, including nausea, vomiting, or gastrointestinal discomfort