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Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)

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"In Davao, kung gusto kang magpaputi, tiis-ganda ka talaga (if you want your skin to be fair, you should sacrifice)

Endosomal escape is crucial for the release of therapeutic agents into the cytoplasm, where they can exert their intended effects (Fig