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Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]

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The most practical approach for many protocols involves starting with a 5mg vial for the early escalation phases and switching to a 10mg vial once weekly doses are higher

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Research has studied its roles in ROS scavenging, xenobiotic detoxification via glutathione S-transferases, maintenance of cellular redox state, and immune cell function