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Tranexamic Acid acts upstream at the signalling stage, making it more effective for persistent pigmentation-driven dark circles that have not responded to downstream inhibitors

Many flavonoids also counteract neuroinflammation and apoptosis

Because this falls outside approved use, anyone considering it should work with a qualified medical professional who can explain the regulatory status, limited evidence, and risks rather than relying on online protocols

Free Radical Biology and Medicine, 62, 1325

By increasing glutathione levels, it is possible to promote antioxidant defence, thereby reducing the risk of developing the diseases associated with oxidative stress