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[6] Preclinical studies in animal models suggest that GLP-1 receptor activation may: Promote neuroplasticity and neurogenesis (formation of new neurons) in the hippocampus, a region often showing reduced volume in depression Modulate neurotransmitter systems , particularly dopamine and serotonin pathways involved in mood regulation and reward processing Reduce neuroinflammation , which is increasingly recognised as contributing to depressive disorders Enhance brain-derived neurotrophic factor (BDNF) expression, a protein crucial for neuronal health and resilience Metabolic improvements associated with GLP-1 therapy may also contribute indirectly to mood benefits

[DOI] [PMC free article] [PubMed] [Google Scholar] 146.Hetz C

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For semaglutide, the typical starting dose is 0.25 mg weekly, increasing to 0.5 mg, then 1.0 mg, and potentially 2.4 mg over several months

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