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Moreover, the context-dependent roles of key microbes, such as Akkermansia muciniphila , highlight their ability to maintain barrier integrity in health but exacerbate inflammation under pathological conditions

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The concurrent inhibition of MEK (trametinib) and glutamine metabolism (V-9302) enhances antitumor efficacy by orchestrating the FOXO3a/FOXM1 axis and autophagy, leading to pyroptosis and cell cycle arrest (135)