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Pharm Res 19:569577 Courreges JP, Vilsboll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O, Verhoeven R, Buganova I, Madsbad S (2008) Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes

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These discoveries suggest that individualized BP management, guided by genetic polymorphisms, endothelial reactivity, or circulating biomarkers such as endothelin-1 and nitric oxide metabolites, could optimize hemodynamic stability and advance BP-lowering strategies beyond uniform protocols 16

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