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GHK-Cu is generally considered to have a favourable tolerability profile in the research literature, particularly when used topically

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It is present at millimolar concentrations intracellularly and performs a foundational role in thiol-based redox signaling, protein function, gene expression, cell differentiation, and cell proliferation

This occurs when the bone marrow suddenly starts producing platelets more effectively, along with a rebound effect where platelet production overshoots normal levels