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However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions

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Furthermore, almost half of the participants were positive for anti-icodec antibodies during the study with the vast majority of these participants also being positive for anti-icodec antibodies cross-reacting to human insulin