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Patients should talk to a doctor if they face: Ongoing insomnia lasting weeks Feeling anxious or restless during the night Extreme tiredness during the day that affects daily tasks Sleep interruptions are getting worse with medication dose increases Talking to a doctor can stop the need to pause treatment

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doi: 10.1038/s41467018-078413 53 SchaedlerTAThorntonJDKruseISchwarzlnderMMeyerAJvan VeenHWet al

doi:10.1016/j.phrs.2020.104722 Chen W, Miao YQ, Fan DJ, Yang SS, Lin X, Meng LK, Tang X