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Mean 1-year weight loss from randomization with liraglutide 3.0 mg was 10.0 kg for those with nausea and/or vomiting ( n =49) and 7.1 kg for those without ( n =43)(difference 2.9 kg (95% confidence interval 0.55.3)
Some may see significant improvements from the very first dose, while others might experience a slower progression
Patients and clinicians should nonetheless remain alert to this possibility, particularly given the substantial weight loss retatrutide has produced in phase 2 trial settings (see the New England Journal of Medicine , 2023)
Fragmented care, such as receiving prescriptions from specialists without informing primary care providers, can further disrupt continuity in therapy
From my review of all the studies I could find, the real answer appears to be somewhere between 2-10 pounds of weight loss from these medications
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