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Clinical Evidence Supporting Semaglutide in PCOS Management Randomized controlled trials have demonstrated that GLP-1 receptor agonists improve insulin sensitivity (measured by HOMA-IR scores) in PCOS populations by 2035%, independent of weight loss alone

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At the level of adipose tissue, GIPR activation promotes fatty acid uptake during energy surplus and fatty acid release during energy deficit, effects that complement the appetite suppression driven by GLP-1R

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HR, 0.63 [CI, 0.18 to 2.18]), rifaximin, or antispasmodics, (0.68% vs