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Nrf2 -null mice suffer from acute hepatotoxicity after acetaminophen exposure ( Nrf2 -null mice ( Nrf2 -null mice are more susceptible to cigarette smoke-induced emphysema (Rangasamy et al., 2004), bleomycin-induced pulmonary fibrosis ( Nrf2 gene has been linked to the reduced expression of Nrf2 and subsequent lung damage caused by hyperoxia ( NRF2 gene also harbors SNPs in the promoter region (Yamamoto et al., 2004), which have been linked to the risk of acute lung injury (Marzec et al., 2007)
Allergy & Immune Research Bundle ( Thymosin Alpha-1 / KPV / BPC-157 )
PMC 5945979
Acknowledgements UD received stipend support from the Laboratory Medicine and Pathobiology Program at the University of Toronto and a Canadian Cancer Society Innovation Grant
Proc Natl Acad Sci U S A 101:37805, PMID: 15004285 Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD (2009) Novel role for glutathione S -transferase pi Regulator of protein S-glutathionylation following oxidative and nitrosative stress
