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Individually, bupropion is used to treat depression and used for smoking cessation, and naltrexone helps treat certain substance misuse, like tobacco and alcohol, Maselli says

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When combined, the two treatments have been shown to result in fast and effective weight loss

The molecule is engineered with a trans-3-hexenoic acid moiety covalently attached at the N-terminal tyrosine, a modification that confers significant resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4)

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase