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Thanks for this great review showing the need to move the paradigm away from just small solute clearance as a measure of PD prescribing

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the combination according to the invention when in unit dose form, contains from 50 mg to 4 g of acetyl L-carnitine inner salt, and from 4 g to propionyl L-carnitine inner salt 50 mg of propionyl L-carnitine inner salt, or an equimolar amount of one of their pharmaceutically acceptable salts, and a suitable dose of the drug useful for the treatment of erectile dysfunction

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Circular (ECFP-like), topological (FP2/FP4), and path-based fingerprints were generated for all reference ligands and Drugbank, Enamine and Biosynth libraries