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Although clinical trials have not identified unexpected pancreatitis signals with Retatrutide, clinicians should remain vigilant for persistent abdominal pain, particularly during dose escalation

Mean inflammatory profiles were calculated by averaging z-scored values within TH1 and TH2 categories for each region

Interestingly, although DAF-16 is similarly activated in both glp-1(-) and fem-3(-) mutants, glp-1(-) shows a greater lifespan extension compared to fem-3(-) , again indicating that whereas DAF-16 is important, other factors are also likely to be key in modulating longevity in response to sterility 6,14,15,16,66

This hypothesis was also validated in a lipopolysaccharide (LPS)-induced systemic inflammation rat model (28)

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