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Wadden and colleagues assessed changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and suicidal ideation or behaviors using the Columbia Suicide Severity Rating Scale in participants with overweight or obesity using semaglutide 2.4 mg or placebo

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Hormonal status: Perimenopausal and postmenopausal women may see a slower response due to estrogen-driven collagen decline

Biochemical Pharmacology 147:141-152

GLP-1 regulates blood glucose levels through several mechanisms, including stimulation of glucose-dependent secretion of insulin, suppression of pancreatic glucagon release, satiety enhancement, delayed stomach emptying, and reduction of energy intake 7,8,9