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Those with type 1 diabetes or insulin-dependent type 2 diabetes must consult their endocrinologist before fasting on GLP-1s, as fasting reduces calorie intake and can increase hypoglycemia risk without medication adjustment

Furthermore, the influence of the microbiota encompasses a spectrum of RNA modifications, including 5-methylcytosine (m5C) RNA methylation 141,142 and the emerging N4-acetylcytidine (ac4C) RNA acetylation 143,144

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Noncoding RNAs also play a pivotal role