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Cost-effectiveness analyses consistently show that drug treatment becomes economically attractive only in patients with at least stage F2 fibrosis or with high cardiovascular risk, whereas lifestyle modification and, in particular, physical activity that induces exercise-mediated anti-inflammatory effects and dietary changes are the preferred first-line options for early, uncomplicated disease [4547]

Early data shows 24% weight loss over 48 weeks, substantially exceeding semaglutide results

It is also why it needs a slower read

Metabolism disrupting chemicals and metabolic disorders

Many people have prediabetes without knowing it, which is why bloodwork before prescribing can be valuable