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While the medication lasts all week, some patients report feeling the strongest appetite suppression in the first 24 to 48 hours after a dose

812 We came to this conclusion because of the accumulated evidence from multiple studies suggesting that pioglitazone exerts cardiovascular benefit by slowing down, or even reversing, the atherosclerotic process, 810,1215 whereas SGLT2 inhibitors seem to exert their cardiovascular benefits by improving cardiac haemodynamics and reducing heart failure, 810,12 and possibly by switching myocardial fuel metabolism to ketones

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