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Here we explore the evidence for GLP-1R agonist use in pediatric obesity
Based on toxicology reports, the authors divided the population into three mutually exclusive groups: (1) opioid-related deaths with opioids only, (2) opioid-related deaths with opioids and another substances (i.e., benzodiazepines, alcohol, marijuana, gabapentin, or clonidine) but not including stimulants (i.e., cocaine or amphetamines), and (3) opioid-related deaths with opioids and stimulants with or without another substance
Data processing Raw data files from the Exactive Plus and Q Exactive instruments were processed using TraceFinder (Thermo Fisher Scientific) and Progenesis QI (Nonlinear Dynamics)
The GLP-1R interacts with structurally related peptide hormone ligands, such as glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), parathyroid hormone, etc
Micrographs were processed using the Patch Motion Correction and Patch CTF Estimation jobs, then manually curated to remove micrographs with CTF fit resolution cutoffs greater than 5
