A recent study revealed that TDP-43 accumulation within stress granules, together with oxidative stress, collectively induces intra-condensate demixing, leading to a TDP-43-enriched phase that forms pathological cytoplasmic aggregates (Yan et al., 2025)
This point is relevant since acute pancreatitis is an unpredictable and potentially life-threatening disease.7,8 Previous systematic reviews have explored the risk of acute pancreatitis with these drugs.911 However, these studies have evaluated different GLP-1RAs, involved comparisons between different hypoglycaemic drugs without including a placebo arm, did not analyse the different administration regimens of semaglutide, or failed to include the latest published studies
Current research indicates that users of the drug may experience up to 10-20% weight loss
BARI-STEP was an investigator-led trial sponsored by UCL
That drug is orforglipron, Eli Lillys GLP-1 drug that patients administer orally rather than through an injectable pen
