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Possible Side Effects and Precautions Common side effects include: Nausea or vomiting (especially in early weeks) Bloating or mild stomach discomfort Fatigue Rare: pancreatitis or gallbladder issues Important: Never start GLP-1 therapy without consulting a doctor

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A medical consultation is required because not every patient is a candidate

(2) overproduction of GDH in INS-1E cells and in rat and mouse pancreatic islets increased GSIS at high glucose concentrations, suggesting GDH is a rate-limiting step in GSIS [69]