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A recent proteomic study suggested altered mitochondrial function in the cerebrovasculature isolated from deceased cognitively healthy E4 carriers compared to non-E4 carriers, indicating that cerebrovascular bioenergetics may indeed be altered in cognitively healthy E4 carriers (Ojo et al., 2021)

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On the other hand, in lens sections with reduced opacity, the vacuoles are crushed toward the lens nucleus, suggesting that cell proliferation may have contributed to the reduction in opacity 31

Research shows local cold application produces measurable reductions in inflammatory markers similar to whole-body approaches for localized injuries